2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide
PNU74654
CAS: 113906-27-7
Molecular Formula: C19H16N2O3
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide - Names and Identifiers
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide - Physico-chemical Properties
| Molecular Formula | C19H16N2O3 |
| Molar Mass | 320.34 |
| Density | 1.17±0.1 g/cm3(Predicted) |
| Solubility | DMSO: >10mg/mL |
| Appearance | solid |
| Color | white to off-white |
| pKa | 12.12±0.46(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| In vitro study | PNU-74654 binds to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654 involves the two narrow pockets on either side of this hot spot. In NCI-H295 cells,PNU-74654 significantly decreases cell proliferation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol, testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability. |
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.122 ml | 15.608 ml | 31.217 ml |
| 5 mM | 0.624 ml | 3.122 ml | 6.243 ml |
| 10 mM | 0.312 ml | 1.561 ml | 3.122 ml |
| 5 mM | 0.062 ml | 0.312 ml | 0.624 ml |
Last Update：2024-01-02 23:10:35
2-Phenoxybenzoicacid-[(5-methyl-2-furanyl)methylene]hydrazide - Reference Information
| biological activity | PNU-74654 is an inhibitor of the Wnt/β-catenin pathway with an IC50 value of 129.8 μm in NCI-H295 cells. |
| Target | 129.8 μm (Wnt/β-catenin, NCI-H295 cell) |
| in vitro study | PNU-74654 bindings to β-catenin with a K D of 450 nM. The Tcf3/Tcf4-binding surface on β-catenin contains a well-defined hot spot around residues K435 and R469. The binding mode of PNU-74654. In NCI-H295 cells,PNU-74654 significant degradation cell propagation 96 h after treatment, increases early and late apoptosis, decreases nuclear beta-catenin accumulation, impairs CTNNB1/beta-catenin expression and increases beta-catenin target genes 48 h after treatment. No effects are observed on HeLa cells. In NCI-H295 cells, PNU-74654 decreases cortisol testosterone and androstenedione secretion 24 and 48 h after treatment. The SF1 and CYP21A2 mRNA expression as well as the protein levels of STAR and aldosterone synthase are decreased in NCI-H295 cells after 48 h PNU-74654 treatment. In Y1 cells, PNU-74654 impairs corticosterone secretion 24 h after treatment but does not decrease cell viability. |
Last Update：2024-04-09 20:49:11
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Spot supply
Product Name: PNU74654 Visit Supplier Webpage Request for quotationCAS: 113906-27-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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